What 4 metals said. Powerful enough, that depends per case. The bigger the restiriction, the more power you'll need to keep an acceptable air flow from the hood going, but also the more air you'll suck out. It's a balance which you will need to try out to stay economical, or over dimension it to be on the safe side.
And keep the pipes after the venturi free of too many bends and restrictions. The vacuum created by the venturi depends on easy flow from venturi all the way to the exhaust.
another thing to mind is keep your exhaust far from your fresh air inlet, to avoid sucking the fumes back in your lab.
but you'll have to try it yourself.
Even the position where the restriction outlet is in the Y-piece is critical to get the best vacuum generated. A little flow restriction through the fumehood (e.g. a closed fume hood window, vent openings almost closed) actually makes a venturi operate better, but give lower airflow.
Aren't physics great?
So you'll want to have the right ratio pipe diameter vs restriction opening vs fan power /output.
Good luck making something that sucks... air well enough